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Local inhibition of rRNA transcription without nucleolar segregation after targeted ion irradiation of the nucleolus
Nucleoli have attracted interest for their role as cellular stress sensors and as potential targets for cancer treatment. The effect of DNA double-strand breaks (DSBs) in nucleoli on rRNA transcription and nucleolar organisation appears to depend on the agent used to introduce DSBs, DSB frequency an...
Autores principales: | Siebenwirth, Christian, Greubel, Christoph, Drexler, Guido A., Reindl, Judith, Walsh, Dietrich W. M., Schwarz, Benjamin, Sammer, Matthias, Baur, Iris, Pospiech, Helmut, Schmid, Thomas E., Dollinger, Günther, Friedl, Anna A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803363/ https://www.ncbi.nlm.nih.gov/pubmed/31492757 http://dx.doi.org/10.1242/jcs.232181 |
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