Mitochondrial dysfunction increases pro-inflammatory cytokine production and impairs repair and corticosteroid responsiveness in lung epithelium

COPD is characterized by chronic lung inflammation and irreversible lung tissue damage. Inhaled noxious gases, including cigarette smoke, are the major risk factor for COPD. Inhaled smoke first encounters the epithelial lining of the lungs, causing oxidative stress and mitochondrial dysfunction. We...

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Detalles Bibliográficos
Autores principales: Hoffmann, R. F., Jonker, M. R., Brandenburg, S. M., de Bruin, H. G., ten Hacken, N. H. T., van Oosterhout, A. J. M., Heijink, I. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803636/
https://www.ncbi.nlm.nih.gov/pubmed/31636329
http://dx.doi.org/10.1038/s41598-019-51517-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803636/
https://www.ncbi.nlm.nih.gov/pubmed/31636329
http://dx.doi.org/10.1038/s41598-019-51517-x

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