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Metal ions and redox balance regulate distinct amyloid-like aggregation pathways of GAPR-1

Members of the CAP superfamily (Cysteine-rich secretory proteins, Antigen 5, and Pathogenesis-Related 1 proteins) are characterized by the presence of a structurally conserved CAP domain. The common structure-function relationship of this domain is still poorly understood. In this study, we unravel...

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Detalles Bibliográficos
Autores principales: Sheng, Jie, Olrichs, Nick K., Geerts, Willie J., Kaloyanova, Dora V., Helms, J. Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803662/
https://www.ncbi.nlm.nih.gov/pubmed/31636315
http://dx.doi.org/10.1038/s41598-019-51232-7