Rigorous sampling of docking poses unveils binding hypothesis for the halogenated ligands of L-type Amino acid Transporter 1 (LAT1)

L-type Amino acid Transporter 1 (LAT1) plays a significant role in the growth and propagation of cancer cells by facilitating the cross-membrane transport of essential nutrients, and is an attractive drug target. Several halogen-containing L-phenylalanine-based ligands display high affinity and high...

Descripción completa

Detalles Bibliográficos
Autores principales: Singh, Natesh, Villoutreix, Bruno O., Ecker, Gerhard F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803698/
https://www.ncbi.nlm.nih.gov/pubmed/31636293
http://dx.doi.org/10.1038/s41598-019-51455-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803698/
https://www.ncbi.nlm.nih.gov/pubmed/31636293
http://dx.doi.org/10.1038/s41598-019-51455-8

Ejemplares similares