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Rigorous sampling of docking poses unveils binding hypothesis for the halogenated ligands of L-type Amino acid Transporter 1 (LAT1)

L-type Amino acid Transporter 1 (LAT1) plays a significant role in the growth and propagation of cancer cells by facilitating the cross-membrane transport of essential nutrients, and is an attractive drug target. Several halogen-containing L-phenylalanine-based ligands display high affinity and high...

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Detalles Bibliográficos
Autores principales:	Singh, Natesh, Villoutreix, Bruno O., Ecker, Gerhard F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803698/ https://www.ncbi.nlm.nih.gov/pubmed/31636293 http://dx.doi.org/10.1038/s41598-019-51455-8

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