Differentially Methylated Super-Enhancers Regulate Target Gene Expression in Human Cancer

Current literature suggests that epigenetically regulated super-enhancers (SEs) are drivers of aberrant gene expression in cancers. Many tumor types are still missing chromatin data to define cancer-specific SEs and their role in carcinogenesis. In this work, we develop a simple pipeline, which can...

Descripción completa

Detalles Bibliográficos
Autores principales: Flam, Emily L., Danilova, Ludmila, Kelley, Dylan Z., Stavrovskaya, Elena, Guo, Theresa, Considine, Michael, Qian, Jiang, Califano, Joseph A., Favorov, Alexander, Fertig, Elana J., Gaykalova, Daria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803762/
https://www.ncbi.nlm.nih.gov/pubmed/31636280
http://dx.doi.org/10.1038/s41598-019-51018-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803762/
https://www.ncbi.nlm.nih.gov/pubmed/31636280
http://dx.doi.org/10.1038/s41598-019-51018-x

Ejemplares similares