Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity

Imatinib, an Abelson (ABL) tyrosine kinase inhibitor, is a lead molecular-targeted drug against chronic myelogenous leukemia (CML). To overcome its resistance and adverse effects, new inhibitors of ABL kinase are needed. Our previous study showed that the benzyl ester of gypsogenin (1c), a pentacycl...

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Detalles Bibliográficos
Autores principales: I. Ciftci, Halil, O. Radwan, Mohamed, E. Ozturk, Safiye, Ulusoy, N. Gokce, Sozer, Ece, E. Ellakwa, Doha, Ocak, Zeynep, Can, Mustafa, F.S. Ali, Taha, I. Abd-Alla, Howaida, Yayli, Nurettin, Tateishi, Hiroshi, Otsuka, Masami, Fujita, Mikako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804044/
https://www.ncbi.nlm.nih.gov/pubmed/31574910
http://dx.doi.org/10.3390/molecules24193535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804044/
https://www.ncbi.nlm.nih.gov/pubmed/31574910
http://dx.doi.org/10.3390/molecules24193535

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