Solid-Phase Chemical Synthesis of Stable Isotope-Labeled RNA to Aid Structure and Dynamics Studies by NMR Spectroscopy

RNA structure and dynamic studies by NMR spectroscopy suffer from chemical shift overlap and line broadening, both of which become worse as RNA size increases. Incorporation of stable isotope labels into RNA has provided several solutions to these limitations. Nevertheless, the only method to circum...

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Detalles Bibliográficos
Autores principales: Becette, Owen, Olenginski, Lukasz T., Dayie, Theodore K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804060/
https://www.ncbi.nlm.nih.gov/pubmed/31557861
http://dx.doi.org/10.3390/molecules24193476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804060/
https://www.ncbi.nlm.nih.gov/pubmed/31557861
http://dx.doi.org/10.3390/molecules24193476

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