Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth

Thymidylate synthase (TS) is a prominent drug target for different cancer types. However, the prolonged use of its classical inhibitors, substrate analogs that bind at the active site, leads to TS overexpression and drug resistance in the clinic. In the effort to identify anti-TS drugs with new mode...

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Detalles Bibliográficos
Autores principales: Pacifico, Salvatore, Santucci, Matteo, Luciani, Rosaria, Saxena, Puneet, Linciano, Pasquale, Ponterini, Glauco, Lauriola, Angela, D’Arca, Domenico, Marverti, Gaetano, Guerrini, Remo, Costi, Maria Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804113/
https://www.ncbi.nlm.nih.gov/pubmed/31561530
http://dx.doi.org/10.3390/molecules24193493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804113/
https://www.ncbi.nlm.nih.gov/pubmed/31561530
http://dx.doi.org/10.3390/molecules24193493

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