Design, Synthesis, and Biological Evaluation of Novel Thienopyrimidine Derivatives as PI3Kα Inhibitors

Three series of novel thienopyrimidine derivatives 9a–l, 15a–l, and 18a–h were designed and synthesized, and their IC(50) values against four cancer cell lines HepG-2, A549, PC-3, and MCF-7 were evaluated. Most compounds show moderate cytotoxicity against the tested cancer cell lines. The most promi...

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Detalles Bibliográficos
Autores principales: Yu, Lide, Wang, Qinqin, Wang, Caolin, Zhang, Binliang, Yang, Zunhua, Fang, Yuanying, Zhu, Wufu, Zheng, Pengwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804295/
https://www.ncbi.nlm.nih.gov/pubmed/31547116
http://dx.doi.org/10.3390/molecules24193422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804295/
https://www.ncbi.nlm.nih.gov/pubmed/31547116
http://dx.doi.org/10.3390/molecules24193422

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