Direct interaction of DNMT inhibitors to PrP(C) suppresses pathogenic process of prion

The conversion of the normal cellular prion protein (PrP(C)) to the misfolded pathogenic scrapie prion protein (PrP(Sc)) is the biochemical hallmark of prion replication. So far, various chemical compounds that inhibit this conformational conversion have been identified. Here, we report the novel an...

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Detalles Bibliográficos
Autores principales: Kim, Dae-Hwan, Ren, Chunyan, Ryou, Chongsuk, Li, Jiaojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804459/
https://www.ncbi.nlm.nih.gov/pubmed/31649845
http://dx.doi.org/10.1016/j.apsb.2019.04.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804459/
https://www.ncbi.nlm.nih.gov/pubmed/31649845
http://dx.doi.org/10.1016/j.apsb.2019.04.001

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