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Direct interaction of DNMT inhibitors to PrP(C) suppresses pathogenic process of prion
The conversion of the normal cellular prion protein (PrP(C)) to the misfolded pathogenic scrapie prion protein (PrP(Sc)) is the biochemical hallmark of prion replication. So far, various chemical compounds that inhibit this conformational conversion have been identified. Here, we report the novel an...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804459/ https://www.ncbi.nlm.nih.gov/pubmed/31649845 http://dx.doi.org/10.1016/j.apsb.2019.04.001 |