Synergistic antitumor activity of artesunate and HDAC inhibitors through elevating heme synthesis via synergistic upregulation of ALAS1 expression

Artemisinin and its derivatives (ARTs) were reported to display heme-dependent antitumor activity. On the other hand, histone deacetylase inhibitors (HDACi) were known to be able to promote heme synthesis in erythroid cells. Nevertheless, the effect of HDACi on heme homeostasis in non-erythrocytes r...

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Detalles Bibliográficos
Autores principales: Chen, Cai-Ping, Chen, Kun, Feng, Zhiqi, Wen, Xiaoan, Sun, Hongbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804493/
https://www.ncbi.nlm.nih.gov/pubmed/31649844
http://dx.doi.org/10.1016/j.apsb.2019.05.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804493/
https://www.ncbi.nlm.nih.gov/pubmed/31649844
http://dx.doi.org/10.1016/j.apsb.2019.05.001

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