Structural simplification: an efficient strategy in lead optimization

The trend toward designing large hydrophobic molecules for lead optimization is often associated with poor drug-likeness and high attrition rates in drug discovery and development. Structural simplification is a powerful strategy for improving the efficiency and success rate of drug design by avoidi...

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Detalles Bibliográficos
Autores principales: Wang, Shengzheng, Dong, Guoqiang, Sheng, Chunquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804494/
https://www.ncbi.nlm.nih.gov/pubmed/31649841
http://dx.doi.org/10.1016/j.apsb.2019.05.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804494/
https://www.ncbi.nlm.nih.gov/pubmed/31649841
http://dx.doi.org/10.1016/j.apsb.2019.05.004

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