STING Restricts oHSV Replication and Spread in Resistant MPNSTs but Is Dispensable for Basal IFN-Stimulated Gene Upregulation

Malignant peripheral nerve sheath tumors (MPNSTs) are an aggressive soft-tissue sarcoma amenable only to surgical resection. Oncolytic herpes simplex viruses (oHSVs) are a promising experimental therapy. We previously showed that basal interferon (IFN) and nuclear factor κB (NFκB) signaling upregula...

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Detalles Bibliográficos
Autores principales: Lee, Joel M., Ghonime, Mohammed G., Cassady, Kevin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804519/
https://www.ncbi.nlm.nih.gov/pubmed/31650029
http://dx.doi.org/10.1016/j.omto.2019.09.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804519/
https://www.ncbi.nlm.nih.gov/pubmed/31650029
http://dx.doi.org/10.1016/j.omto.2019.09.001

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