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A note on the determination of non-inferiority margins with application in oncology clinical trials()
The goal of a non-inferiority trial is to evaluate whether the effect of an experimental treatment is not inferior to that of the active control. Determination of an appropriate non-inferiority margin is critical to the demonstration of non-inferiority. A commonly used method is called the fixed-mar...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804591/ https://www.ncbi.nlm.nih.gov/pubmed/31650074 http://dx.doi.org/10.1016/j.conctc.2019.100454 |