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Conditional disruption of the osterix gene in chondrocytes during early postnatal growth impairs secondary ossification in the mouse tibial epiphysis

In our previous studies, we have found that the prepubertal increase in thyroid hormone levels induces osterix (Osx) signaling in hypertrophic chondrocytes to transdifferentiate them into osteoblasts. To test if Osx expressed in chondrocytes directly contributes to transdifferentiation and secondary...

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Detalles Bibliográficos
Autores principales: Xing, Weirong, Godwin, Catrina, Pourteymoor, Sheila, Mohan, Subburaman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804621/
https://www.ncbi.nlm.nih.gov/pubmed/31646014
http://dx.doi.org/10.1038/s41413-019-0064-9