Sustained Akt signaling in articular chondrocytes causes osteoarthritis via oxidative stress-induced senescence in mice

Osteoarthritis (OA) is an age-related disorder that is strongly associated with chondrocyte senescence. The causal link between disruptive PTEN/Akt signaling and chondrocyte senescence and the underlying mechanism are unclear. In this study, we found activated Akt signaling in human OA cartilage as...

Descripción completa

Detalles Bibliográficos
Autores principales: Xie, Jing, Lin, Jingting, Wei, Min, Teng, Yan, He, Qi, Yang, Guan, Yang, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804644/
https://www.ncbi.nlm.nih.gov/pubmed/31646013
http://dx.doi.org/10.1038/s41413-019-0062-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804644/
https://www.ncbi.nlm.nih.gov/pubmed/31646013
http://dx.doi.org/10.1038/s41413-019-0062-y

Ejemplares similares