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Alleviation of paclitaxel-induced mechanical hypersensitivity and hyperalgesic priming with AMPK activators in male and female mice
AMP-activated protein kinase (AMPK) is an energy-sensing kinase that has emerged as a novel therapeutic target for pain due to its ability to inhibit mechanistic target of rapamycin (mTOR) and mitogen activated protein kinase (MAPK) signaling, two signaling pathways that are linked to pain promotion...
Autores principales: | Inyang, Kufreobong E., McDougal, Timothy A., Ramirez, Eric D., Williams, Marisa, Laumet, Geoffroy, Kavelaars, Annemieke, Heijnen, Cobi J., Burton, Michael, Dussor, Gregory, Price, Theodore J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804652/ https://www.ncbi.nlm.nih.gov/pubmed/31650090 http://dx.doi.org/10.1016/j.ynpai.2019.100037 |
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