Intratumoral heterogeneity and hypoxia gene expression signatures: Is a single biopsy adequate?

BACKGROUND AND PURPOSE: Gene expression signatures are often used to identify hypoxic tumors. However, intratumoral heterogeneity raises concern that multiple biopsies may be necessary to assess global hypoxia status. The objective of this study was to compare the impact of heterogeneity on the disc...

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Detalles Bibliográficos
Autores principales: Lukovic, Jelena, Han, Kathy, Pintilie, Melania, Chaudary, Naz, Hill, Richard P., Fyles, Anthony, Milosevic, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804682/
https://www.ncbi.nlm.nih.gov/pubmed/31650046
http://dx.doi.org/10.1016/j.ctro.2019.09.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804682/
https://www.ncbi.nlm.nih.gov/pubmed/31650046
http://dx.doi.org/10.1016/j.ctro.2019.09.006

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