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Intratumoral heterogeneity and hypoxia gene expression signatures: Is a single biopsy adequate?
BACKGROUND AND PURPOSE: Gene expression signatures are often used to identify hypoxic tumors. However, intratumoral heterogeneity raises concern that multiple biopsies may be necessary to assess global hypoxia status. The objective of this study was to compare the impact of heterogeneity on the disc...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804682/ https://www.ncbi.nlm.nih.gov/pubmed/31650046 http://dx.doi.org/10.1016/j.ctro.2019.09.006 |