Non-antibiotic Small-Molecule Regulation of DHFR-Based Destabilizing Domains In Vivo

The E. coli dihydrofolate reductase (DHFR) destabilizing domain (DD), which shows promise as a biologic tool and potential gene therapy approach, can be utilized to achieve spatial and temporal control of protein abundance in vivo simply by administration of its stabilizing ligand, the routinely pre...

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Detalles Bibliográficos
Autores principales: Peng, Hui, Chau, Viet Q., Phetsang, Wanida, Sebastian, Rebecca M., Stone, M. Rhia L., Datta, Shyamtanu, Renwick, Marian, Tamer, Yusuf T., Toprak, Erdal, Koh, Andrew Y., Blaskovich, Mark A.T., Hulleman, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804886/
https://www.ncbi.nlm.nih.gov/pubmed/31649953
http://dx.doi.org/10.1016/j.omtm.2019.08.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804886/
https://www.ncbi.nlm.nih.gov/pubmed/31649953
http://dx.doi.org/10.1016/j.omtm.2019.08.002

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