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Non-antibiotic Small-Molecule Regulation of DHFR-Based Destabilizing Domains In Vivo
The E. coli dihydrofolate reductase (DHFR) destabilizing domain (DD), which shows promise as a biologic tool and potential gene therapy approach, can be utilized to achieve spatial and temporal control of protein abundance in vivo simply by administration of its stabilizing ligand, the routinely pre...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804886/ https://www.ncbi.nlm.nih.gov/pubmed/31649953 http://dx.doi.org/10.1016/j.omtm.2019.08.002 |