Preclinical Proof-of-Concept, Analytical Development, and Commercial Scale Production of Lentiviral Vector in Adherent Cells

The therapeutic efficacy of a lentiviral vector (LV) expressing the herpes simplex virus thymidine kinase (HSV-TK) was studied in an immunocompetent rat glioblastoma model. Intraperitoneal ganciclovir injections (50 mg/kg/day) were administered for 14 consecutive days, resulting in reduced tumor vol...

Descripción completa

Detalles Bibliográficos
Autores principales: Leinonen, Hanna M., Lipponen, Eevi M., Valkama, Anniina J., Hynynen, Heidi, Oruetxebarria, Igor, Turkki, Vesa, Olsson, Venla, Kurkipuro, Jere, Samaranayake, Haritha, Määttä, Ann-Marie, Parker, Nigel R., Ylä-Herttuala, Seppo, Lesch, Hanna P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804948/
https://www.ncbi.nlm.nih.gov/pubmed/31649956
http://dx.doi.org/10.1016/j.omtm.2019.08.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804948/
https://www.ncbi.nlm.nih.gov/pubmed/31649956
http://dx.doi.org/10.1016/j.omtm.2019.08.006

Ejemplares similares