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Allele-specific enhancer interaction at the Peg3 imprinted domain

The parental allele specificity of mammalian imprinted genes has been evolutionarily well conserved, although its functional constraints and associated mechanisms are not fully understood. In the current study, we generated a mouse mutant with switched active alleles driving the switch from paternal...

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Detalles Bibliográficos
Autores principales: Kim, Joomyeong, Frey, Wesley D., Sharma, Kaustubh, Ghimire, Subash, Teruyama, Ryoichi, Stubbs, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804975/
https://www.ncbi.nlm.nih.gov/pubmed/31639176
http://dx.doi.org/10.1371/journal.pone.0224287