Galectin-1 promotes hepatocellular carcinoma and the combined therapeutic effect of OTX008 galectin-1 inhibitor and sorafenib in tumor cells

BACKGROUND: Galectins are beta-galactose specific binding proteins. In human cancers, including hepatocellular carcinoma (HCC), galectin-1 (Gal-1) is often found to be overexpressed. In order to combat the dismal diagnosis and death rates of HCC, gene silencing and targeted inhibition of Gal-1 was i...

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Detalles Bibliográficos
Autores principales: Leung, Zoe, Ko, Frankie Chi Fat, Tey, Sze Keong, Kwong, Ernest Man Lok, Mao, Xiaowen, Liu, Bonnie Hei Man, Ma, Angel Po Yee, Fung, Yi Man Eva, Che, Chi-Ming, Wong, Danny Ka Ho, Lai, Ching Lung, Ng, Irene Oi-Lin, Yam, Judy Wai Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805403/
https://www.ncbi.nlm.nih.gov/pubmed/31640796
http://dx.doi.org/10.1186/s13046-019-1402-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805403/
https://www.ncbi.nlm.nih.gov/pubmed/31640796
http://dx.doi.org/10.1186/s13046-019-1402-x

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