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A framework for TRIM21-mediated protein depletion in early mouse embryos: recapitulation of Tead4 null phenotype over three days

BACKGROUND: While DNA and RNA methods are routine to disrupt the expression of specific genes, complete understanding of developmental processes requires also protein methods, because: oocytes and early embryos accumulate proteins and these are not directly affected by DNA and RNA methods. When prot...

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Detalles Bibliográficos
Autores principales: Israel, Steffen, Casser, Ellen, Drexler, Hannes C.A., Fuellen, Georg, Boiani, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805607/
https://www.ncbi.nlm.nih.gov/pubmed/31638890
http://dx.doi.org/10.1186/s12864-019-6106-2