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RUNX1 mutations promote leukemogenesis of myeloid malignancies in ASXL1-mutated leukemia
BACKGROUND: Additional sex combs-like 1 (ASXL1) mutations have been described in all forms of myeloid neoplasms including chronic myelomonocytic leukemia (CMML) and associated with inferior outcomes, yet the molecular pathogenesis of ASXL1 mutations (ASXL1-MT) remains poorly understood. Transformati...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805634/ https://www.ncbi.nlm.nih.gov/pubmed/31640815 http://dx.doi.org/10.1186/s13045-019-0789-3 |