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RUNX1 mutations promote leukemogenesis of myeloid malignancies in ASXL1-mutated leukemia

BACKGROUND: Additional sex combs-like 1 (ASXL1) mutations have been described in all forms of myeloid neoplasms including chronic myelomonocytic leukemia (CMML) and associated with inferior outcomes, yet the molecular pathogenesis of ASXL1 mutations (ASXL1-MT) remains poorly understood. Transformati...

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Detalles Bibliográficos
Autores principales:	Bera, Rabindranath, Chiu, Ming-Chun, Huang, Ying-Jung, Lin, Tung-Huei, Kuo, Ming-Chung, Shih, Lee-Yung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805634/ https://www.ncbi.nlm.nih.gov/pubmed/31640815 http://dx.doi.org/10.1186/s13045-019-0789-3

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