Mapping genetic interactions in cancer: a road to rational combination therapies

The discovery of synthetic lethal interactions between poly (ADP-ribose) polymerase (PARP) inhibitors and BRCA genes, which are involved in homologous recombination, led to the approval of PARP inhibition as a monotherapy for patients with BRCA1/2-mutated breast or ovarian cancer. Studies following...

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Detalles Bibliográficos
Autores principales: Tutuncuoglu, Beril, Krogan, Nevan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805649/
https://www.ncbi.nlm.nih.gov/pubmed/31640753
http://dx.doi.org/10.1186/s13073-019-0680-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805649/
https://www.ncbi.nlm.nih.gov/pubmed/31640753
http://dx.doi.org/10.1186/s13073-019-0680-4

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