Unlocking the therapeutic potential of primary tumor-draining lymph nodes

Lymph nodes draining the primary tumor are essential for the initiation of an effective anti-tumor T-cell immune response. However, cancer-derived immune suppressive factors render the tumor-draining lymph nodes (TDLN) immune compromised, enabling tumors to invade and metastasize. Unraveling the dif...

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Autores principales: Rotman, Jossie, Koster, Bas D., Jordanova, Ekaterina S., Heeren, A. Marijne, de Gruijl, Tanja D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Focussed Research Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805797/
https://www.ncbi.nlm.nih.gov/pubmed/30944963
http://dx.doi.org/10.1007/s00262-019-02330-y
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author Rotman, Jossie
Koster, Bas D.
Jordanova, Ekaterina S.
Heeren, A. Marijne
de Gruijl, Tanja D.
author_facet Rotman, Jossie
Koster, Bas D.
Jordanova, Ekaterina S.
Heeren, A. Marijne
de Gruijl, Tanja D.
author_sort Rotman, Jossie
collection PubMed
description Lymph nodes draining the primary tumor are essential for the initiation of an effective anti-tumor T-cell immune response. However, cancer-derived immune suppressive factors render the tumor-draining lymph nodes (TDLN) immune compromised, enabling tumors to invade and metastasize. Unraveling the different mechanisms underlying this immune escape will inform therapeutic intervention strategies to halt tumor spread in early clinical stages. Here, we review our findings from translational studies in melanoma, breast, and cervical cancer and discuss clinical opportunities for local immune modulation of TDLN in each of these indications.
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spelling pubmed-68057972019-11-05 Unlocking the therapeutic potential of primary tumor-draining lymph nodes Rotman, Jossie Koster, Bas D. Jordanova, Ekaterina S. Heeren, A. Marijne de Gruijl, Tanja D. Cancer Immunol Immunother Focussed Research Review Lymph nodes draining the primary tumor are essential for the initiation of an effective anti-tumor T-cell immune response. However, cancer-derived immune suppressive factors render the tumor-draining lymph nodes (TDLN) immune compromised, enabling tumors to invade and metastasize. Unraveling the different mechanisms underlying this immune escape will inform therapeutic intervention strategies to halt tumor spread in early clinical stages. Here, we review our findings from translational studies in melanoma, breast, and cervical cancer and discuss clinical opportunities for local immune modulation of TDLN in each of these indications. Springer Berlin Heidelberg 2019-04-03 2019 /pmc/articles/PMC6805797/ /pubmed/30944963 http://dx.doi.org/10.1007/s00262-019-02330-y Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Focussed Research Review
Rotman, Jossie
Koster, Bas D.
Jordanova, Ekaterina S.
Heeren, A. Marijne
de Gruijl, Tanja D.
Unlocking the therapeutic potential of primary tumor-draining lymph nodes
title Unlocking the therapeutic potential of primary tumor-draining lymph nodes
title_full Unlocking the therapeutic potential of primary tumor-draining lymph nodes
title_fullStr Unlocking the therapeutic potential of primary tumor-draining lymph nodes
title_full_unstemmed Unlocking the therapeutic potential of primary tumor-draining lymph nodes
title_short Unlocking the therapeutic potential of primary tumor-draining lymph nodes
title_sort unlocking the therapeutic potential of primary tumor-draining lymph nodes
topic Focussed Research Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805797/
https://www.ncbi.nlm.nih.gov/pubmed/30944963
http://dx.doi.org/10.1007/s00262-019-02330-y
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