Cargando…

Mitochondrial 3243A > G mutation confers pro-atherogenic and pro-inflammatory properties in MELAS iPS derived endothelial cells

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a mitochondrial disorder that is commonly caused by the m.3243A > G mutation in the MT-TL1 gene encoding for mitochondrial tRNA(Leu(UUR)). While clinical studies reported cerebral infarcts, atherosclero...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pek, Nicole Min Qian, Phua, Qian Hua, Ho, Beatrice Xuan, Pang, Jeremy Kah Sheng, Hor, Jin-Hui, An, Omer, Yang, Henry He, Yu, Yang, Fan, Yong, Ng, Shi-Yan, Soh, Boon-Seng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805858/ https://www.ncbi.nlm.nih.gov/pubmed/31641105 http://dx.doi.org/10.1038/s41419-019-2036-9

Ejemplares similares

Gastrointestinal Involvement in m.3243A>G-associated MELAS
por: Finsterer, Josef, et al.
Publicado: (2017)

Wnt/β-catenin-mediated signaling re-activates proliferation of matured cardiomyocytes
por: Fan, Yong, et al.
Publicado: (2018)

Mitochondrial DNA 3243A>T mutation in a patient with MELAS syndrome
por: Ikeda, Takahiro, et al.
Publicado: (2018)

Applications of miRNAs in cardiac development, disease progression and regeneration
por: Pang, Jeremy Kah Sheng, et al.
Publicado: (2019)

Organoid cultures of MELAS neural cells reveal hyperactive Notch signaling that impacts neurodevelopment
por: Winanto, et al.
Publicado: (2020)

Onset of MELAS due to the m.3243A > G mutation is early if the large phenotypic variability is considered()()
por: Finsterer, Josef, et al.
Publicado: (2016)

Impact of Mitochondrial A3243G Heteroplasmy on Mitochondrial Bioenergetics and Dynamics of Directly Reprogrammed MELAS Neurons
por: Lin, Dar-Shong, et al.
Publicado: (2022)

Ischemic optic neuropathy as first presentation in patient with m.3243 A > G MELAS classic mutation
por: Scarcella, Simone, et al.
Publicado: (2023)

Pro-Atherogenic and Pro-Oxidant Diets Influence Semen and Blood Traits of Rabbit Bucks
por: Mattioli, Simona, et al.
Publicado: (2023)

A Case of MELAS With the m.3243A>G Variant of the MT-TL1 Gene Mimicking Acute Intermittent Porphyria
por: Cai, Wenjie, et al.
Publicado: (2022)

Discovery of novel peptides targeting pro-atherogenic endothelium in disturbed flow regions -Targeted siRNA delivery to pro-atherogenic endothelium in vivo
por: Chung, Jihwa, et al.
Publicado: (2016)

SUN-560 Simvastatin Inhibits the Pro-Inflammatory and Pro-Atherogenic Effects of Cream in Obese Subjects
por: Goyal, Itivrita, et al.
Publicado: (2020)

Disease Modeling Using 3D Organoids Derived from Human Induced Pluripotent Stem Cells
por: Ho, Beatrice Xuan, et al.
Publicado: (2018)

Association between stroke-like episodes and neuronal hyperexcitability in MELAS with m.3243A>G: A case report
por: Sakai, Shota, et al.
Publicado: (2018)

Pioglitazone and Deoxyribonucleoside Combination Treatment Increases Mitochondrial Respiratory Capacity in m.3243A>G MELAS Cybrid Cells
por: Burgin, Harrison J., et al.
Publicado: (2020)

Mitochondrial disorders due to m.3243A>G not meeting diagnostic criteria for MELAS require comprehensive work-up
por: Finsterer, Josef, et al.
Publicado: (2023)

Diacerein inhibits the pro-atherogenic & pro-inflammatory effects of IL-1 on human keratinocytes & endothelial cells
por: Mohan, Girish C., et al.
Publicado: (2017)

Neuroimaging pattern and pathophysiology of cerebellar stroke-like lesions in MELAS with m.3243A>G mutation: a case report
por: Oyama, Munenori, et al.
Publicado: (2020)

Mitochondrial haplotype mutation alleviates respiratory defect of MELAS by restoring taurine modification in tRNA with 3243A > G mutation
por: Ueda, Saori, et al.
Publicado: (2023)

A Sorbent with Synthetic Ligand for Removing Pro-atherogenic and Pro-inflammatory Components from Human Blood Plasma
por: Dmitrieva, O. A., et al.
Publicado: (2021)

Data-independent acquisition-based quantitative proteomic analysis of m.3243A>G MELAS reveals novel potential pathogenesis and therapeutic targets
por: Chang, Xueli, et al.
Publicado: (2022)

Audio Over IP: Building Pro AoIP Systems with Livewire
por: Pizzi, Skip, et al.
Publicado: (2009)

Comments on “A Case of MELAS With the m.3243A>G Variant of the MT-TL1 Gene Mimicking Acute Intermittent Porphyria”
por: Finsterer, Josef
Publicado: (2022)

Re: Comments on “A Case of MELAS With the m.3243A>G Variant of the MT-TL1 Gene Mimicking Acute Intermittent Porphyria”: The Authors Respond
por: Cai, Wenjie, et al.
Publicado: (2022)

Annexin A6 Polymorphism Is Associated with Pro-atherogenic Lipid Profiles and with the Downregulation of Methotrexate on Anti-Atherogenic Lipid Profiles in Psoriasis
por: Zhang, Fuxin, et al.
Publicado: (2022)

NF-κB controls the global pro-inflammatory response in endothelial cells: evidence for the regulation of a pro-atherogenic program
por: Kempe, Sybille, et al.
Publicado: (2005)

Correction of the consequences of mitochondrial 3243A>G mutation in the MT-TL1 gene causing the MELAS syndrome by tRNA import into mitochondria
por: Karicheva, Olga Z., et al.
Publicado: (2011)

MELAS and Kearns–Sayre overlap syndrome due to the mtDNA m. A3243G mutation and large-scale mtDNA deletions
por: Yu, Nian, et al.
Publicado: (2016)

Peptide-mediated delivery of donor mitochondria improves mitochondrial function and cell viability in human cybrid cells with the MELAS A3243G mutation
por: Chang, Jui-Chih, et al.
Publicado: (2017)

Translational stem cell therapy: vascularized skin grafts in skin repair and regeneration
por: Phua, Qian Hua, et al.
Publicado: (2021)

Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs
por: Yang, Yi, et al.
Publicado: (2018)

NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype
por: Karlsen, Tom Rune, et al.
Publicado: (2021)

A Wide Range of 3243A>G/tRNALeu(UUR) (MELAS) Mutation Loads May Segregate in Offspring through the Female Germline Bottleneck
por: Pallotti, Francesco, et al.
Publicado: (2014)

A Patient with MELAS Syndrome Carried an M.3243A>G Mutation in Mitochondrial DNA and Multiple Nuclear Genetic Variants: A Case Report
por: Chu, Xin, et al.
Publicado: (2022)

In Vitro Interactions of Extracellular Histones with LDL Suggest a Potential Pro-Atherogenic Role
por: Pemberton, Alan D., et al.
Publicado: (2010)

Arsenic Exposure Increases Monocyte Adhesion to the Vascular Endothelium, a Pro-Atherogenic Mechanism
por: Lemaire, Maryse, et al.
Publicado: (2015)

Biophysical and Biochemical Outcomes of Chlamydia pneumoniae Infection Promotes Pro-atherogenic Matrix Microenvironment
por: Evani, Shankar J., et al.
Publicado: (2016)

Patients with Concurrent Tuberculosis and Diabetes Have a Pro-Atherogenic Plasma Lipid Profile
por: Vrieling, Frank, et al.
Publicado: (2018)

Anorexia Nervosa Is Associated with a Shift to Pro-Atherogenic Low-Density Lipoprotein Subclasses
por: Stadler, Julia T., et al.
Publicado: (2022)

Lipid Profiles Alter from Pro-Atherogenic into Less Atherogenic and Proinflammatory in Juvenile Idiopathic Arthritis Patients Responding to Anti TNF-α Treatment
por: Yeh, Kuo-Wei, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_k2urh083l7n6ftggqblsbrjcl5