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Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy
Improving efficacy of oncolytic virotherapy remains challenging due to difficulty increasing specificity and immune responses against cancer and limited understanding of its population dynamics. Here, we construct programmable and modular synthetic gene circuits to control adenoviral replication and...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805884/ https://www.ncbi.nlm.nih.gov/pubmed/31641136 http://dx.doi.org/10.1038/s41467-019-12794-2 |