Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy

Improving efficacy of oncolytic virotherapy remains challenging due to difficulty increasing specificity and immune responses against cancer and limited understanding of its population dynamics. Here, we construct programmable and modular synthetic gene circuits to control adenoviral replication and...

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Detalles Bibliográficos
Autores principales: Huang, Huiya, Liu, Yiqi, Liao, Weixi, Cao, Yubing, Liu, Qiang, Guo, Yakun, Lu, Yinying, Xie, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805884/
https://www.ncbi.nlm.nih.gov/pubmed/31641136
http://dx.doi.org/10.1038/s41467-019-12794-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805884/
https://www.ncbi.nlm.nih.gov/pubmed/31641136
http://dx.doi.org/10.1038/s41467-019-12794-2

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