GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity

Immunotherapy involving checkpoint blockades of inhibitory co-receptors is effective in combating cancer. Despite this, the full range of mediators that inhibit T-cell activation and influence anti-tumor immunity is unclear. Here, we identify the GTPase-activating protein (GAP) Rasal1 as a novel TCR...

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Detalles Bibliográficos
Autores principales: Thaker, Youg Raj, Raab, Monika, Strebhardt, Klaus, Rudd, Christopher E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805919/
https://www.ncbi.nlm.nih.gov/pubmed/31641113
http://dx.doi.org/10.1038/s41467-019-12544-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805919/
https://www.ncbi.nlm.nih.gov/pubmed/31641113
http://dx.doi.org/10.1038/s41467-019-12544-4

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