MLH1 deficiency leads to deregulated mitochondrial metabolism

The DNA mismatch repair (MMR) pathway is responsible for the repair of base–base mismatches and insertion/deletion loops that arise during DNA replication. MMR deficiency is currently estimated to be present in 15–17% of colorectal cancer cases and 30% of endometrial cancers. MLH1 is one of the key...

Descripción completa

Detalles Bibliográficos
Autores principales: Rashid, Sukaina, Freitas, Marta O., Cucchi, Danilo, Bridge, Gemma, Yao, Zhi, Gay, Laura, Williams, Marc, Wang, Jun, Suraweera, Nirosha, Silver, Andrew, McDonald, Stuart A. C., Chelala, Claude, Szabadkai, Gyorgy, Martin, Sarah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805956/
https://www.ncbi.nlm.nih.gov/pubmed/31641109
http://dx.doi.org/10.1038/s41419-019-2018-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805956/
https://www.ncbi.nlm.nih.gov/pubmed/31641109
http://dx.doi.org/10.1038/s41419-019-2018-y

Ejemplares similares