The mTOR kinase inhibitor rapamycin enhances the expression and release of pro-inflammatory cytokine interleukin 6 modulating the activation of human microglial cells

Emerging evidence suggests the potential use of rapamycin in treatment of several neurological disorders. The drug readily crosses the blood brain barrier and may exert direct immunomodulatory effects within the brain. Microglia are the main innate immune cells of the brain, thus critically involved...

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Detalles Bibliográficos
Autores principales: Cappoli, Natalia, Mezzogori, Daniele, Tabolacci, Elisabetta, Coletta, Isabella, Navarra, Pierluigi, Pani, Giovambattista, Dello Russo, Cinzia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806201/
https://www.ncbi.nlm.nih.gov/pubmed/31645839
http://dx.doi.org/10.17179/excli2019-1715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806201/
https://www.ncbi.nlm.nih.gov/pubmed/31645839
http://dx.doi.org/10.17179/excli2019-1715

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