Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs

A variety of base editors have been developed to achieve C-to-T editing in different genomic contexts. Here, we compare a panel of five base editors on their C-to-T editing efficiencies and product purity at commonly editable sites, including some human pathogenic C-to-T mutations. We further profil...

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Detalles Bibliográficos
Autores principales: Wang, Ying, Gao, Runze, Wu, Jing, Xiong, Yi-Chun, Wei, Jia, Zhang, Sipin, Yang, Bei, Chen, Jia, Yang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806563/
https://www.ncbi.nlm.nih.gov/pubmed/31647030
http://dx.doi.org/10.1186/s13059-019-1839-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806563/
https://www.ncbi.nlm.nih.gov/pubmed/31647030
http://dx.doi.org/10.1186/s13059-019-1839-4

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