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Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs
A variety of base editors have been developed to achieve C-to-T editing in different genomic contexts. Here, we compare a panel of five base editors on their C-to-T editing efficiencies and product purity at commonly editable sites, including some human pathogenic C-to-T mutations. We further profil...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806563/ https://www.ncbi.nlm.nih.gov/pubmed/31647030 http://dx.doi.org/10.1186/s13059-019-1839-4 |