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The lipid transfer protein Saposin B does not directly bind CD1d for lipid antigen loading
Background: Lipid antigens are presented on the surface of cells by the CD1 family of glycoproteins, which have structural and functional similarity to MHC class I molecules. The hydrophobic lipid antigens are embedded in membranes and inaccessible to the lumenal lipid-binding domain of CD1 molecule...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
F1000 Research Limited
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807164/ https://www.ncbi.nlm.nih.gov/pubmed/31667358 http://dx.doi.org/10.12688/wellcomeopenres.15368.2 |