Inhibition of PDE4 protects neurons against oxygen-glucose deprivation-induced endoplasmic reticulum stress through activation of the Nrf-2/HO-1 pathway

Inhibition of phosphodiesterase 4 (PDE4) produces neuroprotective effects against cerebral ischemia. However, the involved mechanism remains unclear. Augmentation of endoplasmic reticulum (ER) stress promotes neuronal apoptosis, and excessive oxidative stress is an inducer of ER stress. The present...

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Detalles Bibliográficos
Autores principales: Xu, Bingtian, Qin, Yunyun, Li, Dan, Cai, Ningbo, Wu, Jinling, Jiang, Lan, Jie, Limei, Zhou, Zhongzhen, Xu, Jiangping, Wang, Haitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807264/
https://www.ncbi.nlm.nih.gov/pubmed/31639651
http://dx.doi.org/10.1016/j.redox.2019.101342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807264/
https://www.ncbi.nlm.nih.gov/pubmed/31639651
http://dx.doi.org/10.1016/j.redox.2019.101342

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