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Inhibition of PDE4 protects neurons against oxygen-glucose deprivation-induced endoplasmic reticulum stress through activation of the Nrf-2/HO-1 pathway
Inhibition of phosphodiesterase 4 (PDE4) produces neuroprotective effects against cerebral ischemia. However, the involved mechanism remains unclear. Augmentation of endoplasmic reticulum (ER) stress promotes neuronal apoptosis, and excessive oxidative stress is an inducer of ER stress. The present...
Autores principales: | Xu, Bingtian, Qin, Yunyun, Li, Dan, Cai, Ningbo, Wu, Jinling, Jiang, Lan, Jie, Limei, Zhou, Zhongzhen, Xu, Jiangping, Wang, Haitao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807264/ https://www.ncbi.nlm.nih.gov/pubmed/31639651 http://dx.doi.org/10.1016/j.redox.2019.101342 |
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