Type I interferon-dependent CCL4 is induced by a cGAS/STING pathway that bypasses viral inhibition and protects infected tissue, independent of viral burden

Type I interferons (T1-IFN) are critical in the innate immune response, acting upon infected and uninfected cells to initiate an antiviral state by expressing genes that inhibit multiple stages of the lifecycle of many viruses. T1-IFN triggers the production of Interferon-Stimulated Genes (ISGs), ac...

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Detalles Bibliográficos
Autores principales: Parekh, Nikhil J., Krouse, Tracy E., Reider, Irene E., Hobbs, Ryan P., Ward, Brian M., Norbury, Christopher C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6808495/
https://www.ncbi.nlm.nih.gov/pubmed/31603920
http://dx.doi.org/10.1371/journal.ppat.1007778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6808495/
https://www.ncbi.nlm.nih.gov/pubmed/31603920
http://dx.doi.org/10.1371/journal.ppat.1007778

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