614. Metabolic Interventions for the Resensitization of Daptomycin-Resistant (DAP-R) Streptococcus mitis-oralis Strains to DAP In vitro and Ex Vivo in a Simulated Model of Experimental Endocarditis (IE)

BACKGROUND: Streptococcus mitis-oralis is a leading cause of IE. Treatment of this pathogen is limited by frequent high-level β-lactam resistance and the propensity to develop high-level DAP-R during DAP exposure. The current study elucidated key metabolic perturbations associated with high-level DA...

Descripción completa

Detalles Bibliográficos
Autores principales: Somerville, Greg, Powers, Robert, Rose,, Warren, Miro, Jose, Bayer, Arnold, Mishra, Nagendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6808738/
http://dx.doi.org/10.1093/ofid/ofz360.2511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6808738/
http://dx.doi.org/10.1093/ofid/ofz360.2511

Ejemplares similares