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614. Metabolic Interventions for the Resensitization of Daptomycin-Resistant (DAP-R) Streptococcus mitis-oralis Strains to DAP In vitro and Ex Vivo in a Simulated Model of Experimental Endocarditis (IE)

BACKGROUND: Streptococcus mitis-oralis is a leading cause of IE. Treatment of this pathogen is limited by frequent high-level β-lactam resistance and the propensity to develop high-level DAP-R during DAP exposure. The current study elucidated key metabolic perturbations associated with high-level DA...

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Detalles Bibliográficos
Autores principales:	Somerville, Greg, Powers, Robert, Rose,, Warren, Miro, Jose, Bayer, Arnold, Mishra, Nagendra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Abstracts
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6808738/ http://dx.doi.org/10.1093/ofid/ofz360.2511

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