1727. Candida albicans Phosphatidylinositol-(4,5)-Bisphosphate (PIP2) Directs Aberrant Cytokinesis and Septation in Response to Echinocandins, Which Correlates with Fungicidal Activity and Attenuated Virulence

BACKGROUND: We previously showed that highly dynamic PIP2, septin, and PKC-Mkc1 cell wall integrity pathway responses correlate with echinocandin activity against C. albicans and attenuated virulence during invasive candidiasis. Our objectives were to determine whether PIP2 dysregulation in response...

Descripción completa

Detalles Bibliográficos
Autores principales: Badrane, Hassan, Nguyen, Minh-Hong, Clancy, Cornelius J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6809340/
http://dx.doi.org/10.1093/ofid/ofz360.1590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6809340/
http://dx.doi.org/10.1093/ofid/ofz360.1590

Ejemplares similares