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Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry

Identifying neurons that have functional opioid receptors is fundamental for the understanding of the cellular, synaptic and systems actions of opioids. Current techniques are limited to post hoc analyses of fixed tissues. Here we developed a fluorescent probe, naltrexamine-acylimidazole (NAI), to l...

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Detalles Bibliográficos
Autores principales: Arttamangkul, Seksiri, Plazek, Andrew, Platt, Emily J, Jin, Haihong, Murray, Thomas F, Birdsong, William T, Rice, Kenner C, Farrens, David L, Williams, John T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6809603/
https://www.ncbi.nlm.nih.gov/pubmed/31589142
http://dx.doi.org/10.7554/eLife.49319