Cargando…

Building sensory axons: Delivery and distribution of Na(V)1.7 channels and effects of inflammatory mediators

Sodium channel Na(V)1.7 controls firing of nociceptors, and its role in human pain has been validated by genetic and functional studies. However, little is known about Na(V)1.7 trafficking or membrane distribution along sensory axons, which can be a meter or more in length. We show here with single-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Akin, Elizabeth J., Higerd, Grant P., Mis, Malgorzata A., Tanaka, Brian S., Adi, Talia, Liu, Shujun, Dib-Hajj, Fadia B., Waxman, Stephen G., Dib-Hajj, Sulayman D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810356/ https://www.ncbi.nlm.nih.gov/pubmed/31681845 http://dx.doi.org/10.1126/sciadv.aax4755

Ejemplares similares

The fates of internalized Na(V)1.7 channels in sensory neurons: Retrograde cotransport with other ion channels, axon-specific recycling, and degradation
por: Higerd-Rusli, Grant P., et al.
Publicado: (2022)

Paclitaxel increases axonal localization and vesicular trafficking of Na(v)1.7
por: Akin, Elizabeth J, et al.
Publicado: (2021)

Paclitaxel effects on axonal localization and vesicular trafficking of Na(V)1.8
por: Baker, Christopher A., et al.
Publicado: (2023)

Conserved but not critical: Trafficking and function of Na(V)1.7 are independent of highly conserved polybasic motifs
por: Tyagi, Sidharth, et al.
Publicado: (2023)

Inflammation differentially controls transport of depolarizing Nav versus hyperpolarizing Kv channels to drive rat nociceptor activity
por: Higerd-Rusli, Grant P., et al.
Publicado: (2023)

Atypical changes in DRG neuron excitability and complex pain phenotype associated with a Na(v)1.7 mutation that massively hyperpolarizes activation
por: Huang, Jianying, et al.
Publicado: (2018)

Preferential Targeting of Na(v)1.6 Voltage-Gated Na(+) Channels to the Axon Initial Segment during Development
por: Akin, Elizabeth J., et al.
Publicado: (2015)

Na(v)1.7 is the predominant sodium channel in rodent olfactory sensory neurons
por: Ahn, Hye-Sook, et al.
Publicado: (2011)

Effects of ranolazine on wild-type and mutant hNa(v)1.7 channels and on DRG neuron excitability
por: Estacion, Mark, et al.
Publicado: (2010)

Lacosamide Inhibition of Na(V)1.7 Channels Depends on its Interaction With the Voltage Sensor Domain and the Channel Pore
por: Labau, Julie I. R., et al.
Publicado: (2021)

Mutation I136V alters electrophysiological properties of the Na(V)1.7 channel in a family with onset of erythromelalgia in the second decade
por: Cheng, Xiaoyang, et al.
Publicado: (2008)

A novel gain-of-function Na(v)1.7 mutation in a carbamazepine-responsive patient with adult-onset painful peripheral neuropathy
por: Adi, Talia, et al.
Publicado: (2018)

KCNQ variants and pain modulation: a missense variant in Kv7.3 contributes to pain resilience
por: Yuan, Jun-Hui, et al.
Publicado: (2021)

Kv7-specific activators hyperpolarize resting membrane potential and modulate human iPSC-derived sensory neuron excitability
por: Estacion, Mark, et al.
Publicado: (2023)

Conditional knockout of Na(V)1.6 in adult mice ameliorates neuropathic pain
por: Chen, Lubin, et al.
Publicado: (2018)

Mutations at opposite ends of the DIII/S4-S5 linker of sodium channel Na(V)1.7 produce distinct pain disorders
por: Cheng, Xiaoyang, et al.
Publicado: (2010)

Nonmuscle myosin II isoforms interact with sodium channel alpha subunits
por: Dash, Bhagirathi, et al.
Publicado: (2018)

Contributions of Na(V)1.8 and Na(V)1.9 to excitability in human induced pluripotent stem-cell derived somatosensory neurons
por: Alsaloum, Matthew, et al.
Publicado: (2021)

Temperature dependence of erythromelalgia mutation L858F in sodium channel Nav1.7
por: Han, Chongyang, et al.
Publicado: (2007)

Expression of Nav1.7 in DRG neurons extends from peripheral terminals in the skin to central preterminal branches and terminals in the dorsal horn
por: Black, Joel A, et al.
Publicado: (2012)

Multiple myosin motors interact with sodium/potassium-ATPase alpha 1 subunits
por: Dash, Bhagirathi, et al.
Publicado: (2018)

A Novel Gain-of-Function Nav1.9 Mutation in a Child With Episodic Pain
por: Huang, Jianying, et al.
Publicado: (2019)

Paroxysmal extreme pain disorder M1627K mutation in human Na(v)1.7 renders DRG neurons hyperexcitable
por: Dib-Hajj, Sulayman D, et al.
Publicado: (2008)

Nav1.7 is phosphorylated by Fyn tyrosine kinase which modulates channel expression and gating in a cell type-dependent manner
por: Li, Yangyang, et al.
Publicado: (2018)

Network topology of NaV1.7 mutations in sodium channel-related painful disorders
por: Kapetis, Dimos, et al.
Publicado: (2017)

Non-psychotropic phytocannabinoid interactions with voltage-gated sodium channels: An update on cannabidiol and cannabigerol
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2022)

Brain activity associated with pain in inherited erythromelalgia: stimulus-free pain engages brain areas involved in valuation and learning
por: Geha, Paul, et al.
Publicado: (2018)

The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development
por: Asiedu, Marina N., et al.
Publicado: (2017)

Oral Administration of PF-01247324, a Subtype-Selective Nav1.8 Blocker, Reverses Cerebellar Deficits in a Mouse Model of Multiple Sclerosis
por: Shields, Shannon D., et al.
Publicado: (2015)

Intra- and interfamily phenotypic diversity in pain syndromes associated with a gain-of-function variant of Na(V)1.7
por: Estacion, Mark, et al.
Publicado: (2011)

Na(v) 1.7 gain-of-function mutation I228M triggers age-dependent nociceptive insensitivity and C-LTMR dysregulation
por: Wimalasena, Nivanthika K., et al.
Publicado: (2023)

Fibroblast growth factor homologous factor 2 (FGF-13) associates with Nav1.7 in DRG neurons and alters its current properties in an isoform-dependent manner
por: Effraim, Philip R., et al.
Publicado: (2019)

Differential aging‐related changes in neurophysiology and gene expression in IB4‐positive and IB4‐negative nociceptive neurons
por: Mis, Malgorzata A., et al.
Publicado: (2018)

Genomic analysis of 21 patients with corneal neuralgia after refractive surgery
por: Yuan, Jun-Hui, et al.
Publicado: (2020)

Familial trigeminal neuralgia – a systematic clinical study with a genomic screen of the neuronal electrogenisome
por: Di Stefano, Giulia, et al.
Publicado: (2020)

High-throughput combined voltage-clamp/current-clamp analysis of freshly isolated neurons
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2023)

Lessons learned in translating pain knowledge into practice
por: Becker, Juliane, et al.
Publicado: (2023)

Differential effect of lacosamide on Na(v)1.7 variants from responsive and non-responsive patients with small fibre neuropathy
por: Labau, Julie I R, et al.
Publicado: (2020)

Therapeutic potential of Pak1 inhibition for pain associated with cutaneous burn injury
por: Guo, Yiqun, et al.
Publicado: (2018)

Screening Fluorescent Voltage Indicators with Spontaneously Spiking HEK Cells
por: Park, Jeehae, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_sc6mlvsglrrt7086eoqjq4qv7r