1550. PK-PD Relationship and PK Driver of Efficacy of the Novel Antibacterial Lysin Exebacase (CF-301) in Pre-Clinical Models

BACKGROUND: Exebacase (CF-301) is a novel lysin with rapid bacteriolytic and anti-biofilm activity against S. aureus, pronounced synergy with antibiotics and low propensity for resistance. Exebacase has undergone Phase 1–2 trials. This work was to develop pharmacokinetic (PK) model in animal and det...

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Detalles Bibliográficos
Autores principales: Ghahramani, Parviz, Chiu, Joannellyn, Asempa, Tomefa E, Abdelraouf, Kamilia, Nicolau, David P, Abdel Hady, Wessam, Xiong, Yan, Bayer, Arnold, Carabeo, Teresa, Cassino, Cara, Schuch, Raymond, Lehoux, Dario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810366/
http://dx.doi.org/10.1093/ofid/ofz360.1414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810366/
http://dx.doi.org/10.1093/ofid/ofz360.1414

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