600. β-Lactam Resistance Mechanisms in Pseudomonas aeruginosa Isolates Analyzed Using Whole-Genome Sequencing (WGS) and Transcriptions Analysis and Their Impact in Resistance to New β-Lactam/β-Lactamase Inhibitors

BACKGROUND: Ceftazidime–avibactam (CAZ-AVI) and ceftolozane-tazobactam (C-T) display excellent antipseudomonal activity, but Pseudomonas aeruginosa (PSA) susceptibility against these agents can be affected by acquired resistance genes and mutations. We evaluated resistance mechanisms against these a...

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Detalles Bibliográficos
Autores principales: Castanheira, Mariana, Doyle, Timothy B, Hubler, Cory, Healy, Matthew, Smith, Caitlin J, Mendes, Rodrigo E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810560/
http://dx.doi.org/10.1093/ofid/ofz360.669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810560/
http://dx.doi.org/10.1093/ofid/ofz360.669

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